Levels of ghrelin hormone in obese patients before and after surgery gastric sleeve or vertical gastrectomy in the Dr. Teodoro Maldonado Carbo Hospital of Guayaquil -Ecuador from nov 2015 to december 2016

Abstract

The hormone ghrelin is a peptide of 28 amino acids, with linear structure, of gastrointestinal origin, is produced mainly in the stomach, with appetite-activating capacity. The Gastric Sleeve at present, in our country as a worldwide, is the very successful treatment for patients with morbid obesity, which achieve a greater loss of excess weight and a considerable decrease in hormone levels ghrelin. The aim of this work is to determine the behavior of hormone levels Ghrelin in pre and post obese patients Gastric Sleeve in hospital Dr. Teodoro Maldonado Carbo from Guayaquil from Nov. 2015 to Dec. 2016, through pre-and postoperative blood sampling, in 91 patients diagnosed with morbid obesity, aged 25-65 years. Most frequent preoperative weight 101 to 110 kg 20.87% (19 patients) and 91 to 100kg 18.68% (17 patients).Most frequent post-surgical weight 81 to 90 kg was 18.68% (17 patients) and 91 a 100 kg was 21.87% (20 patients). BMI: More frequent preoperative, more than 40 was 64.83% (59 patients); more frequent postoperative BMI over 40% was 38.5% (35 patients). Significant decrease in post-surgical hormone Ghrelin from 30 to 50%. Weight loss 9 to 13% decreased BMI and comorbidities -hypertension, diabetes and dyslipidemia. Hospital stay was 3 days (interval 3 to 15 days), the first 82 cases of 3 to 4 days; there maining 8 from 3 to 15 days.